FIGURE

Fig. 4

ID

ZDB-FIG-150326-50

Publication

Hamilton et al., 2014 - Clinically Approved Iron Chelators Influence Zebrafish Mortality, Hatching Morphology and Cardiac Function

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Fig. 4

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Fig. 4

Zebrafish larvae morphology after 72 hpf of exposure to iron chelators.

A: Representative optical images of zebrafish morphology after 72 hpf exposure to DFO, L1 and ICL 670. Zebrafish kept in DMSO was used as control. Embryos treated with 1 mM ICL-670 did not survive to hatch (DNS); while those treated with 0.25 mM and 0.5 mM hatched abnormally and had bent bodies (shown with arrows). Images were captured at 2X magnification. B: Representative optical images of zebrafish morphology after 72 hpf exposure to DFO, L1 and ICL 670. Higher magnification (4X) shows edema in L1 and ICL-670 treated embryos. No abnormalities were observed in DFO treated embryos up to concentrations of 1 mM. Images were captured at 4X magnification.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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