FIGURE

Fig. 2

ID

ZDB-FIG-150129-2

Publication

Zhang et al., 2014 - Identification of Annexin A4 as a hepatopancreas factor involved in liver cell survival

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Fig. 2

Anxa4 is bound by 2F11 and is expressed in tissues labeled by 2F11. (a) and (b) A 2F11 immuno-precipitated band (arrow in (a)) was analyzed by peptide mass fingerprinting, yielding peptide sequences (colored text in (b)) that match zebrafish Anxa4. (c)-(g′) Anxa4 is expressed in the developing zebrafish foregut (orange arrow), pronephric ducts (magenta arrowheads), dorsal pancreas (yellow arrows), liver bud (red arrowheads), lateral lines (turquoise arrowheads), and hatching gland (green arrowheads). (h)-(k′) The ventral view of Tg(sox17:GFP) with anxa4 transcript (h) and (j) or 2F11 labeling (i), (i′), (k) and (k′) of the liver (L), ventral pancreas (vP), and dorsal pancreas (dP) at 34 hpf (h) and (I′) and 47 hpf (j) and (k′). (l) and (m′) At 80 hpf, both anxa4 transcripts (l) and 2F11 (m) and (m′) are found in the gallbladder (GB), hepatopancreatic ducts, including extrahepatic duct (EHD), common bile duct (CBD), extrapancreatic duct (EPD), intrapancreatic duct (IPD) and intrahepatic duct (IHD), intestinal secretory cells (yellow arrowheads), and mesenchymal cells around the swim bladder (turquoise arrowheads).

Expression Data

Genes:	anxa4 GFP
Antibody:	Ab-2F11
Fish:	WT s870Tg gz15Tg; jh1Tg; m1018Tg
Anatomical Terms:	anterior pancreatic bud common bile duct endoderm extrahepatic duct extrapancreatic duct gall bladder hatching gland intestinal bulb primordium intestine cell intrahepatic bile duct intrapancreatic duct lateral line liver mesenchymal cell pancreatic bud posterior pancreatic bud pronephric duct
Stage Range:	14-19 somites to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 395(1), Zhang, D., Golubkov, V.S., Han, W., Correa, R.G., Zhou, Y., Lee, S., Strongin, A.Y., Dong, P.D., Identification of Annexin A4 as a hepatopancreas factor involved in liver cell survival, 96-110, Copyright (2014) with permission from Elsevier. Full text @ Dev. Biol.