FIGURE

Fig. 2

ID

ZDB-FIG-150129-10

Publication

Zhao et al., 2014 - Leptin and IL-6 Family Cytokines Synergize to Stimulate Müller Glia Reprogramming and Retina Regeneration

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Fig. 2

The Jak/Stat3 Signaling Pathway Is Necessary for Retina Regeneration

(A) BrdU immunofluorescence shows that the Jak inhibitors P6 and JSI-124 suppress progenitor formation at 4 dpi. The asterisk marks the injury site (needle poke) and arrows point to MG-derived progenitors.

(B) Quantification of BrdU⁺ progenitors in (A). p < 0.001, n = 4.

(C) qPCR shows that the Jak inhibitors P6 and JSI-124 inhibit reprogramming gene induction at 2 dpi; p < 0.01, p < 0.001; n = 4, 4, and 5 for DMSO, P6, and JSI-124, respectively.

Error bars, SD. Scale bars, 20 µm (A). See also Figure S3.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Conditions:	chemical treatment: pharmaceutical, physical alteration: retina chemical treatment: pharmaceutical, physical alteration: retina
Observed In:	Muller cell cell population proliferation
Stage:	Adult

Phenotype Detail

Acknowledgments

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