Fig. 3
- ID
- ZDB-FIG-141007-65
- Publication
- Tryon et al., 2014 - Clonal Analysis of kit ligand a Functional Expression Reveals Lineage-Specific Competence to Promote Melanocyte Rescue in the Mutant Regenerating Caudal Fin
- Other Figures
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Multiple clone lineages are competent to support melanocyte rescue in the regenerating fins of kitlgatc244b mutants following expression of kitlga. A-A′′′. Skin clone that has not been subjected to heat shock shows no rescued melanocytes associated with the kitlga clone. B-B′′′. Dermal fibroblasts robustly support melanocyte rescue as a result of expressing kitlga. C-E. Skin (C-C′′′), osteoblasts (D-D′′′), and vasculature (E-E′′′) can support melanocyte rescue, but with a greater degree of variability of the strength of rescue as compared to dermal fibroblasts. F-F′′′. Lateral line clones (black arrow) could be distinguished from intra-ray glia by their neuromasts (asterisk) and were never able to rescue melanocytes. Strong rescue is shown in B′′′, C′′′, and E′′′. Weak rescue is shown in D′′′. Red dashed lines indicate the amputation plane. Yellow rectangles in A and A′ indicate insets magnified in greater detail in A′′ and A′′′, respectively. Grey arrowheads indicate newly differentiated kit-dependent melanocytes. Black arrowheads indicate previously differentiated melanocytes drawn into the regenerate from the stump. Scale bar = 250 mm. |