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ZFIN ID: ZDB-FIG-140902-18
Jopling et al., 2014 - Endosome-to-Plasma Membrane Recycling of VEGFR2 Receptor Tyrosine Kinase Regulates Endothelial Function and Blood Vessel Formation. Cells   3:363-85 Full text @ Cells
EXPRESSION / LABELING:
Gene:
Fish:
Knockdown Reagents:
Anatomical Terms:
Stage: Long-pec
PHENOTYPE:
Fish:
Knockdown Reagents:
Observed In:
Stage: Long-pec

Fig. 8

Rab4a regulates vascular development in transgenic zebrafish. Fluorescence microscopy on representative (A) control, (B) Rab4a-depleted or (C) Rab11a-depleted zebrafish transgenic lines (morphants) expressing Fli1:EGFP. Arrows in panel B denote defects in blood vessel formation in Rab4a-depleted animals. (D) Immunoblotting of control, Rab4a- or Rab11a-depleted transgenic zebrafish extracts.

Gene Expression Details
Gene Antibody Fish Conditions Stage Anatomy Assay
EGFP y1Tg control Long-pec dorsal longitudinal anastomotic vessel IFL
Long-pec intersegmental vessel IFL
Long-pec vascular endothelium IFL
y1Tg + MO1-rab11a standard conditions Long-pec dorsal longitudinal anastomotic vessel IFL
Long-pec intersegmental vessel IFL
Long-pec vascular endothelium IFL
y1Tg + MO1-rab4a standard conditions Long-pec dorsal longitudinal anastomotic vessel IFL
Long-pec intersegmental vessel IFL
Long-pec vascular endothelium IFL
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
y1Tg + MO1-rab11a standard conditions Long-pec vasculature malformed, abnormal
y1Tg + MO1-rab4a standard conditions Long-pec dorsal longitudinal anastomotic vessel malformed, abnormal
Long-pec intersegmental vessel malformed, abnormal
Long-pec vasculature malformed, abnormal
Acknowledgments:
ZFIN wishes to thank the journal Cells for permission to reproduce figures from this article. Please note that this material may be protected by copyright. Full text @ Cells