FIGURE

Fig. 4

ID

ZDB-FIG-140821-6

Publication

Loh et al., 2014 - Zebrafish yap1 plays a role in differentiation of hair cells in posterior lateral line

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Fig. 4

(A–D) Primordium I (PrimI) in yap1 morphants. (E) Size of PrimI at 36 hpf. (E, F) Mantle cells of neuromast in 72 hpf ET20 yap1 morphants. (G–H) Mechanoreceptors of neuromast (red, DiAsp) in 72 hpf ET33-mi60a embryos, support cells (green). (I–L) hair cells. (J–L) Loss of yap1 abolished the functionality of hair cells in SqET4 transgenics, stained with DiAsp (red); it was rescued with yap1 mRNA injection. (M–O) Mismatch MO, yap1 MO or yap1 MO with prox1 mRNA were co-injected with a marker (Cascade Blue) into single cell of SqET4 embryos at 16-cell stage. (P) The schematic drawing of injected single cell (blue), any one of the middle four cells, at 16-cell stage. Scale bar = 10 μm.

Expression Data

Gene:	EGFP
Fish:	sqet4Et sqet20Et sqet33mi60AEt zf106Tg sqet4Et + MO4-tp53 + MO5-yap1 sqet20Et + MO4-tp53 + MO5-yap1 sqet33mi60AEt + MO4-tp53 + MO5-yap1 zf106Tg + MO4-tp53 + MO5-yap1
Knockdown Reagents:	MO4-tp53 MO5-yap1
Anatomical Terms:	lateral line primordium neuromast hair cell neuromast mantle cell neuromast support cell
Stage Range:	Prim-25 to Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sqet4Et + MO4-tp53 + MO5-yap1 zf106Tg + MO4-tp53 + MO5-yap1
Knockdown Reagents:	MO4-tp53 MO5-yap1
Observed In:	lateral line primordium neuromast hair cell
Stage Range:	Prim-25 to Long-pec

Phenotype Detail

Acknowledgments

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