FIGURE

Fig. S2

ID

ZDB-FIG-140612-31

Publication

Giustiniani et al., 2014 - Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy

Other Figures

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Fig. S2

FKBP52 is expressed ubiquitously in the nervous system in zebrafish. (A) Sequence alignment of Danio rerio (Z) and human (H) FKBP52. D. rerio FKBP52 amino acid sequence shares 62% of identities (amino acids in red) and 83% of homologies with the human ortholog. Based on the 3D structure of human FKBP52 (1), four domains are delineated. The single underlining indicates peptidyl-prolyl isomerase (PPIase) and FK506-binding domain, the double underlining indicates PPIase-like domain, the thick underlining indicates tetratricopetide repeat domain, and the dashed underlining indicates calmodulin binding domain. (B) RT-PCR shows the expression of FKBP52 during development. NCtrl, negative control. (C) Whole-mount FKBP52 in situ hybridization shows its maternal ubiquitous expression [1.25 h postfertilization (hpf)] that persists until 32 hpf. (Scale bars: 200 µm.)

Expression Data

Gene:	fkbp4
Fish:	WT
Anatomical Term:	whole organism
Stage Range:	8-cell to Prim-15

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA