FIGURE

Fig. 6

ID

ZDB-FIG-140522-20

Publication

Keupp et al., 2013 - Mutations in the interleukin receptor IL11RA cause autosomal recessive Crouzon-like craniosynostosis

Other Figures

Fig. 6

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Fig. 6

Il11ra expression in mouse and zebrafish sutures. (A-B) Sagittal cryosections of P0 mouse heads; scale bars: 100µm. (A) Upper row, histological staining with hematoxylin and eosin shows the coronal suture (arrow heads) and surrounding tissue. Lower row, immunofluorescence staining displays Il11ra localization (red) in the granular layer of the skin (arrow) and around the coronal suture tips (asterisks). Nuclei were stained with DAPI (blue). White lines mark cranial bone plates. (B) Immunofluorescence staining of Il11ra (red) shows protein in the lambdoidal suture (asterisks). Nuclei were stained with DAPI (blue). White lines mark cranial bone plates. (C) In situ hybridization of il11ra mRNA on sagittal paraffin sections of adult zebrafish heads. il11ra is expressed within the coronal sutures (left) and anteriorly in craniofacial bone fusions (right, arrows) within areas of bone contact; scale bars: 100µm.

Expression Data

Gene:	il11ra
Fish:	WT
Anatomical Terms:	cranium fibrous joint frontal-parietal joint
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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