Gene
il11ra
- ID
- ZDB-GENE-030131-5942
- Name
- interleukin 11 receptor subunit alpha
- Symbol
- il11ra Nomenclature History
- Previous Names
-
- fi26e06
- wu:fi26e06
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable interleukin-11 binding activity and interleukin-11 receptor activity. Acts upstream of or within cardiac muscle tissue regeneration and fin regeneration. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Is expressed in cranium and frontal-parietal joint. Orthologous to human IL11RA (interleukin 11 receptor subunit alpha).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cssl:d199 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| bns251 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| sa12313 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34862 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45397 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa45398 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-il11ra | (2) | |
| CRISPR2-il11ra | Allanki et al., 2021 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Craniosynostosis and dental anomalies | 614188 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR003530 | Long hematopoietin receptor, soluble alpha chain, conserved site |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR013151 | Immunoglobulin-like beta-sandwich domain |
| Family | IPR053073 | Interleukin-11/Interleukin-27 subunit beta |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Fibronectin type III | Fibronectin type III superfamily | Immunoglobulin-like beta-sandwich domain | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | Interleukin-11/Interleukin-27 subunit beta | Long hematopoietin receptor, soluble alpha chain, conserved site |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A8WH84 | InterPro | 402 | ||||||||
| UniProtKB:A0AB32U0T3 | InterPro | 434 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
il11ra-201
(1)
|
Ensembl | 2,821 nt | ||
| mRNA |
il11ra-202
(1)
|
Ensembl | 2,809 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:LOXP-LOX2272-mCherry-LOXP-il11ra-V5-2A-GFP-LOX2272) |
| 1 | Allanki et al., 2021 | ||
| Tg(hsp70l:LOXP-TagBFP-LOXP-il11ra-2A-mCherry) |
| 1 | Allanki et al., 2021 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-190H24 | ||
| Contained in | BAC | DKEYP-84G6 | ZFIN Curated Data | |
| Encodes | EST | fi26e06 | ||
| Encodes | cDNA | cssl:d199 | Bushell et al., 2007 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001113499 (1) | 9745 nt | ||
| Genomic | GenBank:CR376801 (1) | 199715 nt | ||
| Polypeptide | UniProtKB:A0AB32U0T3 (1) | 434 aa |
- Allanki, S., Strilic, B., Scheinberger, L., Onderwater, Y.L., Marks, A., Günther, S., Preussner, J., Kikhi, K., Looso, M., Stainier, D.Y.R., Reischauer, S. (2021) Interleukin-11 signaling promotes cellular reprogramming and limits fibrotic scarring during tissue regeneration. Science advances. 7:eabg6497
- Mitra, S., Sharma, P., Kaur, S., Khursheed, M.A., Gupta, S., Ahuja, R., Kurup, A.J., Chaudhary, M., Ramachandran, R. (2018) Histone Deacetylase-Mediated Müller Glia Reprogramming through Her4.1-Lin28a Axis Is Essential for Retina Regeneration in Zebrafish. iScience. 7:68-84
- Pei, W., Xu, L., Huang, S.C., Pettie, K., Idol, J., Rissone, A., Jimenez, E., Sinclair, J.W., Slevin, C., Varshney, G.K., Jones, M., Carrington, B., Bishop, K., Huang, H., Sood, R., Lin, S., Burgess, S.M. (2018) Guided genetic screen to identify genes essential in the regeneration of hair cells and other tissues. NPJ Regenerative medicine. 3:11
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Elsaeidi, F., Bemben, M.A., Zhao, X.F., and Goldman, D. (2014) Jak/Stat signaling stimulates zebrafish optic nerve regeneration and overcomes the inhibitory actions of Socs3 and Sfpq. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(7):2632-2644
- Zhao, X.F., Wan, J., Powell, C., Ramachandran, R., Myers, M.G., Goldman, D. (2014) Leptin and IL-6 Family Cytokines Synergize to Stimulate Müller Glia Reprogramming and Retina Regeneration. Cell Reports. 9(1):272-84
- Fang, Y., Gupta, V., Karra, R., Holdway, J.E., Kikuchi, K., and Poss, K.D. (2013) Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. Proceedings of the National Academy of Sciences of the United States of America. 110(33):13416-13421
- Keupp, K., Li, Y., Vargel, I., Hoischen, A., Richardson, R., Neveling, K., Alanay, Y., Uz, E., Elciolu, N., Rachwalski, M., Kamaci, S., Tunçbilek, G., Akin, B., Grötzinger, J., Konas, E., Mavili, E., Müller-Newen, G., Collmann, H., Roscioli, T., Buckley, M.F., Yigit, G., Gilissen, C., Kress, W., Veltman, J., Hammerschmidt, M., Akarsu, N.A., and Wollnik, B. (2013) Mutations in the interleukin receptor IL11RA cause autosomal recessive Crouzon-like craniosynostosis. Molecular Genetics and Genomic Medicine. 1(4):223-237
- Liongue, C., and Ward, A.C. (2007) Evolution of Class I cytokine receptors. BMC Evolutionary Biology. 7(1):120
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