FIGURE

Fig. 6

ID

ZDB-FIG-140425-26

Publication

Rengarajan et al., 2014 - Endocytosis of Fgf8 is a double-stage process and regulates spreading and signaling

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Fig. 6

Inhibition of Fgf8 transport from early to late endosome does not alter signaling range.

Analysis of localization of Fgf8-GFP during inhibition of endocytic transport from early to late endosomes by treatment with Bafilomycin A1. Embryos were injected with Fgf8-GFP along with the early endosomal marker Rab5 or membrane marker mCherry at one cell stage, treated with 100 nM Bafilomycin A1 at 30% epiboly stage for a period of 1 hr and subjected to live imaging using confocal microscopy at 50% epiboly stage. At 75% epiboly stage embryos were fixed and stained for erm expression by ISH. Circle highlight co-localization of Rab5 and Fgf8, white arrows point to typical Fgf8 localizations, and balck arrows visualize the extend of the pea3 expression domain.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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