FIGURE

Fig. 3

ID

ZDB-FIG-140321-22

Publication

Chen et al., 2001 - Analysis of the zebrafish smoothened mutant reveals conserved and divergent functions of hedgehog activity

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Fig. 3

Essential and conserved role of vertebrate smo in Hh signaling. (A,B) Lateral view of wild-type and mutant embryos at 24 hpf (A) and 12 hpf (B) demonstrating the absence of ptc1 expression in the mutants. (C-E) ptc-1 expression in response to manipulation of Hh signaling components in wild-type and mutant embryos indicates a conserved role of smo in the pathway in zebrafish. Embryos were injected at one- to two-cell stages and ptc1 expression is determined at 12 hpf. (C) shh mRNA injection. (D) twhh mRNA injection. (E) PKI mRNA injection. Arrows indicate ectopic expression.

Expression Data

Gene:	ptch2
Fish:	smo^hi229Tg smo^hi1640Tg
Anatomical Term:	midbrain ventral region
Stage Range:	5-9 somites to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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