FIGURE

Fig. 5

ID

ZDB-FIG-140305-74

Publication

Appel et al., 1998 - Regulation of neuronal specification in the zebrafish spinal cord by Delta function

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Fig. 5

Disruption of lateral inhibition reduces the number of secondary motoneurons. (A) Lateral view of a 36 h control embryo labeled with zn5, which identifies secondary motoneurons (brackets) and ventral nerves (arrows) exiting the spinal cord. (B) Similar view of a 36 h embryo injected with X-Delta-1STU and nlacZ mRNAs. Lineage tracer (blue staining) is expressed in small clusters of spinal cord cells. Outside the clusters, zn5 labeling looks essentially normal. Cells within lineage-marked clusters are largely zn5-negative, showing that secondary motoneurons have not differentiated. Ventral nerves (arrows) appear reduced in size, suggesting the presence of fewer motor axons than in normal embryos. Scale bar, 20 μM.

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

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