FIGURE

Fig. 2

ID

ZDB-FIG-131231-18

Publication

Luna et al., 2013 - Amyloid-beta and APP Deficiencies Cause Severe Cerebrovascular Defects: Important Work for an Old Villain

Other Figures

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Fig. 2

Cerebrovascular defects in APP-deficient zebrafish embryos.

(A) Dark field (top) and fluorescence (bottom) images of a control transgenic embryo at 3 dpf shows vascular structures dues to EGFP expression in endothelial cells. (B) Confocal image (projected stack) of cerebrovascular structures in the head of the fish in A. (C) Dark field (top) and fluorescence (bottom) images of a zAPP-MO embryo at 3 dpf. (D) Confocal image (projected stack) of cerebrovascular structures in the head of the fish in C. (E) Dark field (top) and fluorescence (bottom) images of a ctrl-MO embryo at 3 dpf. (F) Confocal image (projected stack) of cerebrovascular structures in the head of the fish in E. (G) Graph showing the number of CtA branches in control (N = 30), zAPP-MO (N = 15), and ctrl-MO (N = 15) zebrafish at 3 dpf (***, P < 8.9e-16). (H) Mean CtA branch lengths in control (N = 28), zAPP-MO (N = 14), and ctrl-MO (N = 8) embryos at 3 dpf (***, P < 9.8e-23); scale bars = 100 μm.

Expression Data

Gene:	EGFP
Fish:	s843Tg s843Tg + MO1-appa + MO1-appb
Knockdown Reagents:	MO1-appa MO1-appb
Anatomical Terms:	cranial vasculature vasculature
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	s843Tg + MO1-appa + MO1-appb
Knockdown Reagents:	MO1-appa MO1-appb
Observed In:	ball central artery whole organism
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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