FIGURE

Fig. 6

ID

ZDB-FIG-131015-32

Publication

Solis et al., 2013 - Conserved roles of the prion protein domains on subcellular localization and cell-cell adhesion

Other Figures

All Figure Page

Back to All Figure Page

Fig. 6

Overexpression (OE) of mouse and zebrafish PrP constructs in early zebrafish embryos.

Embryos were microinjected with mRNAs encoding all mouse and zebrafish EGFP-tagged PrP constructs. A) OE of mouse or zebrafish WT PrPs in early embryos produces a gain-of-function phenotype characterized by asymmetric gastrulation at 6 hpf. B–D) The activities of mouse and zebrafish constructs were evaluated morphologically by quantifying the proportion of 6 hpf embryos exhibiting the OE phenotype (asymmetric gastrulation). Three independent experiments were analyzed (average n = 30 embryos). Triple asterisks [***] indicate statistically significant reduction in activity at p<0.001; one-way ANOVA test; error bars represent SEM.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS One