FIGURE

Fig. 8

ID

ZDB-FIG-130826-65

Publication

Costa et al., 2013 - GRG5/AES Interacts with T-Cell Factor 4 (TCF4) and Downregulates Wnt Signaling in Human Cells and Zebrafish Embryos

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Fig. 8

GRG5/AES reduces both mortality and axis duplication in β-catenin-overexpressing embryos.

A) One blastomere of 8-cell stage zebrafish embryos was injected with the indicated combinations of β-catenin (50 pg), grg5/aes (500 pg) and dntcf4 (500 pg) mRNAs. Partial and complete axis duplications were grouped to avoid ambiguity. The total number of scored embryos (n) is indicated at the lower part of the panel. B) Example of 24hpf embryo showing complete axis duplication (induced by β-catenin injection), with two discernible heads (arrows), notochords (asterisks) and tails (arrowheads). Dorsal view, anterior to the left. C) Example of 24hpf embryo injected with β-catenin showing extreme dorsalization.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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