FIGURE

Fig. 5

ID

ZDB-FIG-130822-40

Publication

Sah et al., 2013 - Ion channel-kinase TRPM7 is required for maintaining cardiac automaticity

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Fig. 5

Trpm7 deleted SAN exhibit impaired automaticity with slowed diastolic Ca²⁺ rise. Ca²⁺ transients measured by high-speed line-scanning confocal microscopy in (A) WT SAN and (B) KO^αMHC-Cre SAN under basal conditions (Top) and after stimulation with ISO: 2 nM (Middle) and 100 nM (Bottom). (C) Mean Ca²⁺ transient frequency and (D) Ca²⁺ transient length in WT SAN compared with KO^αMHC-Cre SAN under basal conditions and after stimulation with 2 nM and 100 nM ISO. (E) Representative Ca²⁺ transients from WT (Left) and KO^αMHC-Cre (Right) showing the slope of diastolic Ca²⁺ rise (Ca²⁺ ramp). (F) Mean slope of the diastolic Ca²⁺ ramp in WT and KO^αMHC-Cre under increasing ISO concentrations. *P < 0.05, **P < 0.01.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA