FIGURE

Fig. 6

ID

ZDB-FIG-130719-6

Publication

Riera et al., 2013 - CERKL Knockdown Causes Retinal Degeneration in Zebrafish

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Fig. 6

Eye histology in control and ZFcerkl morpholino-injected embryos at 72 hpf.

(A) Zebrafish eye sections were stained with H&E. Control morphants (coMO) showed normal retinal lamination with three cell layers (GCL, INL, and ONL). In “mild” acMO-injected embryos, lamination did not occur and the three layers were not visible. The retinal pigment epithelium (RPE) developed normally in control and ZFcerkl morphants. (B) Immunostaining with anti-rhodopsin and (C) anti-PNA identified rod and cone outer segments, respectively, in control and doMO morphants. Outer segments were absent in acMO morphants. Nuclei were stained with DAPI. Some nonspecific staining was seen in the lens when stained with PNA. Photographs were at×40 magnification.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-cerkl
Knockdown Reagent:	MO1-cerkl
Observed In:	lens photoreceptor outer segment layer retina layer formation retinal pigment epithelium development
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

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