FIGURE

Fig. 9

ID

ZDB-FIG-130524-25

Publication

Roach et al., 2013 - Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility

Other Figures

(all 8)

All Figure Page

Back to All Figure Page

Fig. 9

Migration of enteric neural precursors within ascl1a-/- embryos. At 74 hpf enteric neural precursors, as demonstrated by phox2b RNA in situ hybridization, have migrated in two lateral lines to the distal end of the digestive system (A). In genotyped ascl1a-/- embryos, enteric neural precursors also migrate in similar duplicate lateral lines to reach the distal intestine at 74 hpf (B) similar to WT (A). At 96 hpf, phox2b is distributed around the circumference of the WT intestine (C) while they are no longer present in the ascl1a-/- intestine at the same time (D). Scale bars represent 50 μm.

Expression Data

Gene:	phox2bb
Fish:	AB ascl1a^{t25215/t25215}
Anatomical Term:	enteric nervous system
Stage Range:	Protruding-mouth to Day 4

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	ascl1a^{t25215/t25215}
Observed In:	enteric nervous system enteric nervous system development enteric neuron
Stage Range:	Protruding-mouth to Day 4

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 376(2), Roach, G., Heath Wallace, R., Cameron, A., Emrah Ozel, R., Hongay, C.F., Baral, R., Andreescu, S., and Wallace, K.N., Loss of ascl1a prevents secretory cell differentiation within the zebrafish intestinal epithelium resulting in a loss of distal intestinal motility, 171-186, Copyright (2013) with permission from Elsevier. Full text @ Dev. Biol.