FIGURE

Fig. 5

ID

ZDB-FIG-130430-11

Publication

Uribe et al., 2013 - Aminoglycoside-Induced Hair Cell Death of Inner Ear Organs Causes Functional Deficits in Adult Zebrafish (Danio rerio)

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Fig. 5

Gentamicin treatment increases the numbers of TUNEL-labeled cells in the adult utricle.

Adult wildtype zebrafish received either a single intraperitoneal injection of (A) buffer or (B) 250 mg/kg gentamicin and allowed to recover for either 4 or 24 hours (4 hour data is shown). Fixed utricles were processed using a TUNEL-kit to label apoptotic cells (green cells) and co-labeled with DAPI (blue cells). (A–B) Low power (10X) images of the utricle reveals few TUNEL-labeled cells scattered throughout the utricle of a (A) buffer-treated animal but more cells with TUNEL-labeling in the (B) gentamicin-treated animal. (C) Mean number of TUNEL-labeled cells (± SD) in the utricles of buffer- or gentamicin-injected zebrafish. *p<0.05 or ***p<0.001; n = 9–12; M = medial, R = rostral.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT
Condition:	chemical treatment by injection: gentamycin
Observed In:	utricle apoptotic process
Stage:	Adult

Phenotype Detail

Acknowledgments

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