FIGURE

Fig. 2

ID

ZDB-FIG-130220-23

Publication

Henriques et al., 2013 - Telomerase is required for zebrafish lifespan

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Fig. 2

First-generation telomerase mutant zebrafish show progressive body wasting and die prematurely.

A) Representative images of tert^+/+ and tert^-/- zebrafish show that tert^-/- fish are born and develop normally until reproductive maturity at ~3 months of age, but progressively lose body mass since then, B) represented as an overall reduction in width/length ratios as compared to wild-type siblings N≥6 p<0.001. This progressive wasting phenotype is accompanied by increase in mortality. C) Kaplan-Meier curve showing that tert^-/- zebrafish have significantly reduced survival when compared to tert^+/+ siblings (AVG lifespan 9 versus >22 months (p<0.005)). N = 24 tert^-/-; N = 45 tert^+/+. Data are represented as mean +/- SEM. Scale bar = 1 cm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tert^{hu3430/hu3430} (AB)
Observed In:	whole organism
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ PLoS Genet.