FIGURE

Fig. 4

ID

ZDB-FIG-130118-36

Publication

Kaiser et al., 2012 - Amyloid Beta precursor protein and prion protein have a conserved interaction affecting cell adhesion and CNS development

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Fig. 4

Apoptosis is synergistically increased when Appa and Prp1 levels are reduced. A–D.

Zebrafish injected with a control morpholino (MO), low dose (sub-effective) prp1 MO, low dose (sub-effective) appa MO, or a combination of sub-effective appa and prp1 MOs (A–D, respectively) showed increased abundance of activated-caspase 3-positive cells (A′–D′, respectively). Higher doses of MOs used in this same assay showed individual MOs can also produce this effect (Fig. S7). E. Activated caspase 3-positive cells were slightly increased when low doses of prp1 or appa MOs were injected alone and synergistically increased when they were combined in one injection solution. N = 5. ** = P<0.01, * = P<0.05.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-prnpb + MO2-appa
Knockdown Reagents:	MO1-prnpb MO2-appa
Observed In:	activation of cysteine-type endopeptidase activity involved in apoptotic process
Stage:	Prim-5

Phenotype Detail

Acknowledgments

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