FIGURE

Fig. 5

ID

ZDB-FIG-130115-15

Publication

Mellman et al., 2012 - Fibrillin-2b regulates endocardial morphogenesis in zebrafish

Other Figures

All Figure Page

Back to All Figure Page

Fig. 5

Electron microscopy study of endocardium details adhesion defects. Sections of 30 hpf wild-type (A), (C), (E) and sco^te382 mutants (B), (D), (F) at 9.4 kX (A) and (B) and 19 kX (C) and (D). Panels E and F correspond to the boxed areas of C and D, respectively. Wild-type endocardial cells (A), (C), (E) form a continuous layer between the cardiac jelly and the cardiac lumen. Mutant cells (B), (D), (F) fail to adhere to each other leading to a disorganized barrier, and allowing cardiac jelly to leak into the lumen. In (B), (D) and (F), the lumen and blood cells are located in the upper-left, while space between the endocardium and myocardium (which the cardiac jelly should occupy) is in the lower-right. Black arrows point to breaks between endocardial cells. CJ: cardiac jelly; BC: blood cell; L: lumen.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	fbn2b^{te382a/te382a}; pku300^{te382b/te382b}
Observed In:	cardiac jelly endocardium endocardium cell
Stage:	Prim-15

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 372(1), Mellman, K., Huisken, J., Dinsmore, C., Hoppe, C., and Stainier, D.Y., Fibrillin-2b regulates endocardial morphogenesis in zebrafish, 111-119, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.