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Fig. 2

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ZDB-FIG-121210-19

Publication

Cao et al., 2012 - High mobility group B proteins regulate mesoderm formation and dorsoventral patterning during zebrafish and Xenopus early development

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Fig. 2

HMGB3 up-regulates gsc expression at different stages and inhibits ntl expression at the injection site. Embryos were injected with hmgb3 mRNA alone or coinjected with membrane GFP mRNA, they were cultured to various stages for in situ hybridization using gsc or ntl probe. (A-C) gsc expression in control embryos at the 50% epiboly (A), shield (B) and bud (C) stages. (D-F) gsc expression in hmgb3-injected embryos at the 50% epiboly (D), shield (E) and bud (F) stages. (G and H) ntl expression in GFP-injected (G) and GFP and hmgb3 coinjected (H) embryos. Brown color indicates membrane GFP-labeled cells. (I) Summary of the down-regulated ntl expression domain in hmgb3-injected embryos, as analyzed by double in situ hybridizations using ntl and gsc probes (see Fig. S2). The numbers on the top indicate total embryos analyzed from two independent experiments

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 129(9-12), Cao, J.M., Li, S.Q., Zhang, H.W., and Shi, D.L., High mobility group B proteins regulate mesoderm formation and dorsoventral patterning during zebrafish and Xenopus early development, 263-274, Copyright (2012) with permission from Elsevier. Full text @ Mech. Dev.