FIGURE

Fig. 7

ID

ZDB-FIG-121130-40

Publication

Lee et al., 2012 - Zebrafish larvae exposed to ginkgotoxin exhibit seizure-like behavior that is relieved by pyridoxal-5'-phosphate, GABA and anti-epileptic drugs

Other Figures

All Figure Page

Back to All Figure Page

Fig. 7

Primidone relieved the larval seizure-like behavior induced by ginkgotoxin exposure but not by PTZ treatment. Zebrafish larvae at 3 dpf were incubated in water containing convulsing agents with or without the presence of primidone for 2 hours before video recording and analyzed for the stage distribution (left) and total distance of larval displacement (right). The larval behavior was categorized into three stages on the basis of the characteristics of their swimming patterns: stage 0, no or low swimming activity; stage I, mildly increased swimming activity; stage II, whole body convulsion, erupting swimming and misshaped. There were at least ten larvae included for each group. Bars show mean + s.e.m. **P<0.0001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB
Conditions:	chemical treatment by environment: primidone chemical treatment by environment: pentetrazol chemical treatment by environment: primidone
Observed In:	swimming behavior
Stage:	Protruding-mouth

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Dis. Model. Mech.