FIGURE

Fig. 4

ID

ZDB-FIG-121102-36

Publication

Zhang et al., 2010 - Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers

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Fig. 4

Overexpression of fgf8a synergizes with mutation of p53 in MPNST development. Kaplan–Meier curves indicate when externally visible tumors were first observed in fish with the indicated genotypes. All fish were progeny of the same four pairs born the same day. Tumor type was confirmed by histological analysis, and fish with neuroblastoma (1 in p53 HOM, Hag^D1 het, 1 in p53 het, Hag^D1 het) were excluded from the analysis. No MPNSTs were found in p53 WT, Hag^D1 heterozygous fish. P values comparing genotyped pairs are shown.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	tp53^zdf1/zdf1 tp53^zdf1/+ tp53^zdf1/+; fbxw4^dhiD1Tg/+ tp53^zdf1/zdf1; fbxw4^dhiD1Tg/+
Observed In:	peripheral nervous system neurofibrosarcoma
Stage:	Adult

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA