FIGURE

Fig. 1

ID

ZDB-FIG-120727-35

Publication

Niu et al., 2012 - Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish

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Fig. 1

The sq198 mutation confers hypoplastic digestive organs and malformed skeletal cartilage. (A–D) WISH using markers specifically for the liver (fabp10a) (A), exocrine pancreas (trypsin) (B), intestine (fabp2) (C), and endocrine pancreas (insulin) (D) on 3 dpf wildtype (WT) and mutant (mu) embryos. (E) Alcian blue staining showing the branchial arches 1–7 in WT and sq198 (mu) at 4 dpf. (F,G) Histochemical staining of alkaline phosphatase (AP) did not reveal obvious difference between 3 dpf wildtype (WT) and mutant (mu) blood vessels (F) whilst the head region of the pronephric ducts appears thinner in the mutant (G).

Expression Data

Genes:	fabp2 fabp10a ins prss1
Fish:	AB sec13^sq198/sq198 (AB)
Anatomical Terms:	endocrine pancreas exocrine pancreas intestine liver
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	sec13^sq198/sq198 (AB)
Observed In:	exocrine pancreas intestine liver pharyngeal arch 3-7 pronephric duct
Stage Range:	Protruding-mouth to Day 4

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 367(2), Niu, X., Gao, C., Jan Lo, L., Luo, Y., Meng, C., Hong, J., Hong, W., and Peng, J., Sec13 safeguards the integrity of the endoplasmic reticulum and organogenesis of the digestive system in zebrafish, 197-207, Copyright (2012) with permission from Elsevier. Full text @ Dev. Biol.