ZFIN ID: ZDB-FIG-120314-2
Trowe et al., 1996 - Mutations disrupting the ordering and topographic mapping of axons in the retinotectal projection of the zebrafish, Danio rerio. Development (Cambridge, England)   123:439-450
ADDITIONAL FIGURES
PHENOTYPE:
Fish:
Observed In:
Stage: Day 5

Fig. 5

Transverse sections through the tectal lobes of a wild-type fish (A) and three mutants (B,C,D). Before sectioning, nasodorsal RGCs were labeled with DiI and the dye was photoconverted. Medial is to the left, dorsal is up. (A) A wild-type fish. The termination field of the nasodorsal axons occupies the ventral half of the tectum. Black arrows mark the ventral margin of the termination fields in all four pictures, black arrowheads the dorsal margin. The dorsal margin of the tectal lobes is labeled by white arrowheads, the ventral margin by white arrows. The black bar marks the superficialdeep axis of the tectum. (B) In box mutants, the termination field of the nasodorsal axons occupies the ventral half of the tecum, as in wild-type fish. The tectum is compressed along the superficial-deep axis. (C) In nev fish, the termination field of nasodorsal axons reaches into the dorsal side of the tecum. It is compressed along its superficial-deep axis. (D) In woe mutants, nasodorsal axons terminate in two separate fields posteroventrally and posterodorsally in the tectum. The dorsal field is oriented more towards the center of the neuropil than towards the dorsal margin. Scale bars, 50 ┬Ám.

Gene Expression Details No data available
Antibody Labeling Details No data available
Phenotype Details
Fish Conditions Stage Phenotype
cyfip2tr230b/tr230b standard conditions Day 5 optic tectum composition, abnormal
Day 5 optic tectum flattened, abnormal
Day 5 retinal ganglion cell axon displaced, abnormal
Day 5 retinal ganglion cell axon guidance process quality, abnormal
Day 5 retinal ganglion cell axon organization quality, abnormal
extl3tm4/tm4 standard conditions Day 5 diencephalon dorsal region flattened, abnormal
Day 5 midbrain dorsal region flattened, abnormal
Day 5 retinal ganglion cell axon guidance process quality, abnormal
woetr221z/tr221z standard conditions Day 5 optic tectum composition, abnormal
Day 5 retinal ganglion cell axon displaced, abnormal
Day 5 retinal ganglion cell axon guidance process quality, abnormal
Day 5 retinal ganglion cell axon organization quality, abnormal
Acknowledgments:
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.