FIGURE

Fig. 6

ID

ZDB-FIG-120216-95

Publication

Goonesinghe et al., 2012 - Desmosomal cadherins in zebrafish epiboly and gastrulation

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Fig. 6

Knockdown of desmosomal cadherins affects convergent-extension movements. Representative DIC images of wild type and morphant embryos at 9-11 somites to illustrate convergent-extension defects produced by knocking down zfDsc1 and zfDsg2. A-C Dorsal views showing abnormal somite structure. D-F Lateral views showing shortening of embryonic axis (head and tail indicated by upper and lower arrowhweads, respectively). G-L Higher magnification pictures showing medio-lateral widening of somites (double headed arrows in G-I), kinking of notochord (arrows in H, K) and loss of chevron structure of somites (J-L). Scale bars = 100 μm (A-F) and 50 μm (G-L).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	TL + MO1-dsg2.1 TL + MO4-dsc2l
Knockdown Reagents:	MO1-dsg2.1 MO4-dsc2l
Observed In:	convergent extension involved in gastrulation notochord somite whole organism anterior-posterior axis
Stage Range:	5-9 somites to 10-13 somites

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.