Fig. 4
- ID
- ZDB-FIG-120126-58
- Publication
- Lin et al., 2011 - Progenitor expansion in apc mutants is mediated by Jak/Stat signaling
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Jak/Stat signaling does generally mediate Wnt-responsive gene expression or the entire neurogenesis program in apc mutants. (A) axin2 mRNA expression, a general marker for Wnt/β-catenin target gene activation, is increased in apc mutants treated with AG-490 at 36 hpf, compared to controls. Lateral whole-mount views at 36 hpf are shown. (B) Expression of HuC/D, a marker of differentiated neurons, is decreased in the apc mutant hypothalamus, and remains decreased after AG-490 treatment. Confocal projections from the ventral brain surface through the 36 hpf hypothalamus are shown. HuC/D immunohistochemistry is red, TO-PRO-3 nuclear stain is in blue. |