ZFIN Image: Lin et al., 2011, Fig. 4

Image

Figure Caption

Fig. 4

Jak/Stat signaling does generally mediate Wnt-responsive gene expression or the entire neurogenesis program in apc mutants. (A) axin2 mRNA expression, a general marker for Wnt/β-catenin target gene activation, is increased in apc mutants treated with AG-490 at 36 hpf, compared to controls. Lateral whole-mount views at 36 hpf are shown. (B) Expression of HuC/D, a marker of differentiated neurons, is decreased in the apc mutant hypothalamus, and remains decreased after AG-490 treatment. Confocal projections from the ventral brain surface through the 36 hpf hypothalamus are shown. HuC/D immunohistochemistry is red, TO-PRO-3 nuclear stain is in blue.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.