FIGURE

Fig. 4

ID

ZDB-FIG-111102-33

Publication

Kur et al., 2011 - Loss of Lrp2 in zebrafish disrupts pronephric tubular clearance but not forebrain development

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Fig. 4

Lrp2 deficiency disrupts clearance pathways in the pronephric duct. A, B: Whole mount fluorescence microscopy detects accumulation of fluid phase marker FITC-dextran (green) in the wild type but not in the Lrp2-deficient pronephros (arrows in A and B) upon injection into the common cardinal vein. C, D: Immunohistological detection of Lrp2 (red) and FITC-dextran (green) in the pronephros of the indicated genotypes. White lines highlight the position of the pronephric ducts. E: Wild type as well as bugeye and 5cben larvae at 4 dpf were injected with FITC-dextran and the number of larvae with tubular accumulation of tracers evaluated by fluorescence microscopy. Data are given as % ± SEM of all larvae injected. N= 53 (wild type), 15 (bugeye), or 23 (5cben).

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	lrp2a^mw1/mw1 lrp2a^p5bnc/p5bnc
Observed In:	pronephros receptor-mediated endocytosis renal absorption
Stage:	Day 4

Phenotype Detail

Acknowledgments

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