FIGURE

Fig. 8

ID

ZDB-FIG-111021-5

Publication

Sorrell et al., 2011 - Restraint of Fgf8 signaling by retinoic acid signaling is required for proper heart and forelimb formation

Other Figures

All Figure Page

Back to All Figure Page

Fig. 8

RA signaling-deficient embryos have a posterior expansion of Fgf ligands and responsive genes. Control sibling and DEAB treated embryos at 3s probed for the Fgf ligands fgf3 (A–D) and fgf8a (E–H) and the Fgf responsive genes dusp6 (I–L), etv5b (M–P), pea3 (Q–T) and spry4 (U–X). DEAB treated embryos display a posterior expansion of the Fgf ligands and Fgf responsive genes (B, D, F, H, J, L, N, P, R, T, V, X) compared to control siblings (A, C, E, G, I, K, M, O, Q, S, U, W). Bars indicate the overall length of expression within the anterior of the embryo. Arrow indicates the anterior limit of the posterior expression domains. Arrowheads in C, H, K, L, O, P, S, T, W, and X indicate LPM expression. A, B, E, F, I, J, M, N, Q, R, U, and V are lateral views with anterior up and dorsal right. C, D, G, H, K, L, O, P, S, T, W, and X are dorsal views with anterior up.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 358(1), Sorrell, M.R., and Waxman, J.S., Restraint of Fgf8 signaling by retinoic acid signaling is required for proper heart and forelimb formation, 44-55, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.