Fig. 8

Fig. 8

RA signaling-deficient embryos have a posterior expansion of Fgf ligands and responsive genes. Control sibling and DEAB treated embryos at 3s probed for the Fgf ligands fgf3 (A–D) and fgf8a (E–H) and the Fgf responsive genes dusp6 (I–L), etv5b (M–P), pea3 (Q–T) and spry4 (U–X). DEAB treated embryos display a posterior expansion of the Fgf ligands and Fgf responsive genes (B, D, F, H, J, L, N, P, R, T, V, X) compared to control siblings (A, C, E, G, I, K, M, O, Q, S, U, W). Bars indicate the overall length of expression within the anterior of the embryo. Arrow indicates the anterior limit of the posterior expression domains. Arrowheads in C, H, K, L, O, P, S, T, W, and X indicate LPM expression. A, B, E, F, I, J, M, N, Q, R, U, and V are lateral views with anterior up and dorsal right. C, D, G, H, K, L, O, P, S, T, W, and X are dorsal views with anterior up.