FIGURE

Fig. 4

ID

ZDB-FIG-111017-21

Publication

Lightman et al., 2011 - Opposing actions of histone deacetylase 1 and Notch signalling restrict expression of erm and fgf20a to hindbrain rhombomere centres during zebrafish neurogenesis

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Fig. 4

Expression of fgf20a in the hindbrain is restricted to rhombomere centres by the opposing actions of Hdac1 and Notch signalling. In situ hybridisation analysis of fgf20a expression in (A,C) wild-type sibling, (B) hdac1 mutant and (D) mind bomb mutant embryos at 27hpf (A-D). Dorsal views of hindbrain are shown in each panel. Wild-type sibling embryos (A,C) exhibit weak, narrow stripes of fgf20a expression in the hindbrain at 27 hpf that are localised to rhombomere centres (signals in rhombomeres 4, 5 and 6 are indicated by red arrowheads). fgf20a expression is extinguished in the hindbrain of hdac1 mutant embryos (B). By contrast, mind bomb mutant embryos exhibit increased and ectopic expression of fgf20a in a broad domain within the hindbrain that encompasses multiple adjacent rhombomeres (D).

Expression Data

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Antibody Labeling

Phenotype Data

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Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Int. J. Dev. Biol.