FIGURE

Fig. 1

ID

ZDB-FIG-111011-4

Publication

Stevens et al., 2011 - Plasticity of photoreceptor-generating retinal progenitors revealed by prolonged retinoic acid exposure

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Fig. 1

Opsin expression is altered by retinoic acid treatment beginning at the time of retinal neurogenesis. Embryos were treated with DMSO (Cont.; A, B, C), or 0.3 μM RA (D, E, F) at 36 hpf, and at 60 hpf were hybridized as whole mounts with probes corresponding to rod opsin (A, D), red cone opsin (B, E), or blue cone opsin (C, F); views are of whole embryonic eyes; dorsal is up and nasal to the left. In the control (DMSO-treated) embryos, rod photoreceptors are found predominantly in the ventral and dorsal regions (A), while red and blue cones (B, C) are evenly spread across the retina. In RA-treated embryos there is an apparent increase in rods, particularly in central regions of the retina (B), and a decrease in the appearance of red cones, leading to empty patches in the red cone mosaic (E, arrows). Boxed regions in each panel appear at higher magnification in the insets. Bar = 50 μm.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.