FIGURE

Fig. 10

ID

ZDB-FIG-110804-44

Publication

Hortopan et al., 2011 - Aberrant expression of genes necessary for neuronal development and notch signaling in an epileptic mind bomb zebrafish

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Fig. 10

A–H: Confocal live whole-mount images of Gfap:GFP (upper panel) and Dlx5-6:GFP transgenic zebrafish brain (lower panel) in wild-type (left side) and mib^hi904 mutant (right side) at 3 days postfertilization (dpf): dorsal views (A,C,E,G) and lateral views (B,D,F,H). The transgenic line for the glial fibrillary acidic protein (GFAP) drove expression (shown as green fluorescence) initially in the telencephalon and then in the eye and midbrain. Gfap:GFP is also highly prominent in hindbrain in wild-type (WT)siblings with a weak expression pattern in mib^hi904 mutants. Dlx5-6:GFP in mib^hi904 mutants is reduced with only few cells showing expression in diencephalon, eyes, and in the cerebellar region. Images of live zebrafish were obtained using a Leica SP5 confocal scanning fluorescence microscope. Abbreviations as above. Scale bars = 0.25 mm in A–D, and 0.2 mm in E–H.

Expression Data

Gene:	GFP
Fish:	mi2001Tg ot1Tg mib1^{hi904Tg/hi904Tg}; mi2001Tg (AB) mib1^{hi904Tg/hi904Tg}; ot1Tg (AB)
Anatomical Terms:	cerebellum diencephalon hindbrain medulla oblongata midbrain optic tectum retina spinal cord telencephalon
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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