FIGURE

Fig. 7

ID
ZDB-FIG-110516-54
Publication
Lengerke et al., 2011 - Interactions between Cdx genes and retinoic acid modulate early cardiogenesis
Other Figures
All Figure Page
Back to All Figure Page
Fig. 7

Suppression of RA levels expands cardiac myosin expressing-cells (cmlc2) in cdx-deficient embryos, and can be rescued by exogenous RA treatment. Expression of cmlc2 expression in wildtype, cdx4 and cdx1a/4-deficient embryos incubated with DMSO (control), DEAB, or DEAB and RA, was assayed by whole mount in situ hybridization at the 16 somite stage. cdx mutants evinced dramatic expansion of cardiac mesoderm when RA production was abrogated, and this phenotype was rescued by concomitant DEAB and RA treatment.

Expression Data
Gene:
Fish:
Conditions:
Knockdown Reagent:
Anatomical Term:
Stage: 14-19 somites

Expression Detail
Antibody Labeling
Phenotype Data
Fish:
Conditions:
Knockdown Reagent:
Observed In:
Stage: 14-19 somites

Phenotype Detail
Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Developmental Biology, 354(1), Lengerke, C., Wingert, R., Beeretz, M., Grauer, M., Schmidt, A.G., Konantz, M., Daley, G.Q., and Davidson, A.J., Interactions between Cdx genes and retinoic acid modulate early cardiogenesis, 134-142, Copyright (2011) with permission from Elsevier. Full text @ Dev. Biol.
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.