FIGURE

Fig. 6

ID

ZDB-FIG-110322-59

Publication

van der Velden et al., 2011 - The serine-threonine kinase LKB1 is essential for survival under energetic stress in zebrafish

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Fig. 6

Loss of vhl suppresses manifestation of the lkb1 phenotype. (A) High-power images depicting the liver and intestine of live larvae of the indicated genotypes at 7 dpf; anterior is to the left. Note that some yolk (Y) is still present. The intestine is folded, and the liver is clear in the lkb1/vhl larva. (B) Graph showing ATP levels as measured in relative light units (RLU). The lkb1 embryos have very low ATP levels; ATP levels are decreased in vhl and lkb1/vhl embryos but are slightly higher than in lkb1-mutant embryos. (C) Graph representing the metabolic rate of larvae of different genotypes at 3 dpf. The lkb1-mutant larvae have an increased metabolic rate as compared with WT larvae. The vhl larvae display a dramatically low metabolic rate, and the lkb1/vhl larvae also display a low metabolic rate.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	stk11^{hu1960/hu1960} vhl^{hu2117/hu2117} stk11^{hu1968/hu1968}; vhl^{hu2117/hu2117}
Observed In:	intestinal epithelium liver
Stage:	Days 7-13

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA