FIGURE

Fig. 5

ID

ZDB-FIG-110321-7

Publication

Wibowo et al., 2011 - Compartmentalized Notch signaling sustains epithelial mirror symmetry

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Fig. 5

Local and global planar polarization of the neuromast epithelium. (A-D) Hair-cell planar polarity distribution in regenerating and mature neuromasts. Positional values of each polarity are plotted in a Cartesian plane. (A,B) Example of one neuromast (A) and 20 pooled neuromasts (B) in Phase I. (C,D) Example of one neuromast (C) and 22 pooled neuromasts (D) in Phase II/III. (E) Schematic transition of marker gene-expression in prospective UHCPs [weakly Atoh1a+ (pink)], UHCPs, immature and young hair cells [co-expressing SqET4 and Atoh1a (green/red)], and mature hair cells [exclusively SqET4+ (green)]. (F) A Tg[Atoh1a:TdTomato; SqET4] neuromast exemplifies this transition [GFP(+) UHCPs and hair cells (green) and Atoh1a(+) cells (red)]. The white arrowhead indicates mature hair cells on the rostral part of this parallel neuromast. (G) DiASP incorporation into hair cells of Tg[Cldnb:mGFP; SqET4] neuromast, showing the exclusion of mature hair cells from the polar compartments. The white arrowhead indicates immature hair cells on the dorsal part of this parallel neuromast.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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