FIGURE

Fig. 2

ID

ZDB-FIG-101223-16

Publication

Santoriello et al., 2010 - Kita Driven Expression of Oncogenic HRAS Leads to Early Onset and Highly Penetrant Melanoma in Zebrafish

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Fig. 2

kita-GFP-RAS fish develop melanoma.

a?d) Different phenotypes in three-month old kita-GFP-RAS zebrafish: a) control fish; b) black caudal fin; c) large hyper-pigmented tumor; d) hypo-pigmented tumor. e) Percentage of the progeny of kita-GFP-RAS fish incross displaying a black fin phenotype (BF) or tumor (T) at 3 months (mean±SD). f) Lateral view of a fish bearing an infiltrating melanoma of the mouth and head, which also expresses mCherry (g) and GFP-RASV12 (h). H&E staining of parraffin sections of the fish in f) that display infiltrations of melanocytes in the head (i), muscles (k), gills (j). Insets are from control animals. Calibration bars for i?j = 100 μm.

Expression Data

Genes:	EGFP mCherry
Fish:	hzm1Et; io006Tg
Anatomical Term:	head
Stage:	Adult

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	hzm1Et; io006Tg
Observed In:	caudal fin caudal fin adnexal and skin appendage tumor gill melanoma head melanoma mouth melanoma post-vent region melanocytic tumor (all 6)
Stage:	Adult

Phenotype Detail

Acknowledgments

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