FIGURE

Fig. 3

ID

ZDB-FIG-101208-39

Publication

Schneider et al., 2010 - Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning

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Fig. 3

Nkd1 is required for proper DFC migration and KV formation. (A?F) EGFP (Dusp6:d2EGFP) expression in wt (A, C and E) and Nkd1MO^DFC (B, D and F) embryos; DFCs were assessed at 80% epiboly (A and B), tailbud to 1-somite stage (C and D) and at 8-somite stage (E and F). (G and H) Fluorescence image denoting KV cilia in wt (J) and Nkd1MO^DFC (K) embryos. Dusp6:d2EGFP (green) and anti-acetylated tubulin (red) indicate cilia in KV cells. (I) Graph of DFC migration defects. N notes the sample size. ** = p < 0.01 compared to uninjected using Fisher′s exact test.

Expression Data

Gene:	EGFP
Fish:	pt6Tg pt6Tg + MO3-nkd1
Knockdown Reagent:	MO3-nkd1
Anatomical Terms:	forerunner cell group Kupffer's vesicle
Stage Range:	75%-epiboly to 5-9 somites

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	pt6Tg + MO3-nkd1
Knockdown Reagent:	MO3-nkd1
Observed In:	Kupffer's vesicle Kupffer's vesicle cilium
Stage:	5-9 somites

Phenotype Detail

Acknowledgments

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Reprinted from Developmental Biology, 348(1), Schneider, I., Schneider, P.N., Derry, S.W., Lin, S., Barton, L.J., Westfall, T., and Slusarski, D.C., Zebrafish Nkd1 promotes Dvl degradation and is required for left-right patterning, 22-33, Copyright (2010) with permission from Elsevier. Full text @ Dev. Biol.