FIGURE

Fig. 5

ID

ZDB-FIG-101122-66

Publication

North et al., 2010 - PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury

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Fig. 5

PGE2 acts synergistically with NAC to improve APAP toxicity. (A) Zebrafish embryos were treated with APAP at 48 hpf and with dmPGE2 and/or NAC, either concomitantly or with 12-h delay (del). Combined NAC and PGE2 treatment improved liver morphology, assessed by in situ hybridization for lfabp at 96 hpf, even after delayed exposure. (B) Embryo survival is dependent on treatment parameter and is improved by NAC and PGE2 exposure. (C) Caspase 3/7 activity, as indicator of apoptosis, was measured in a luminometric assay and normalized to controls. *ANOVA, n = 10/ treatment for three replicates, P < 0.001.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA