FIGURE

Fig. 4

ID

ZDB-FIG-100628-65

Publication

Kim et al., 2010 - Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish

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Fig. 4

Motile cilia are largely unaffected by the loss of Iguana (Igu) function. Motile cilia (red: acetylated tubulin in a-h) in the pronephros at 48 hpf in igu mutant embryos appeared normal (b), as did those in the olfactory pits (d). By contrast motile cilia were largely absent from the floorplate at 28 hpf (f) and those in Kupffer′s vesicle were significantly reduced in number (h) in 10 somite stage igu mutant embryos. Basal bodies (red: γ-tubulin in i-l) in the igu mutants, by contrast, were formed normally at all stages examined in the floorplate (j) and Kupffer′s vesicle (l). Scale bars: 10 μm

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	dzip1^{ts294e/ts294e}
Observed In:	floor plate ciliary basal body floor plate motile cilium Kupffer's vesicle ciliary basal body Kupffer's vesicle motile cilium olfactory pit cilium pronephros motile cilium
Stage Range:	10-13 somites to Long-pec

Phenotype Detail

Acknowledgments

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Open Access.

Full text @ BMC Biol.