FIGURE

Fig. 6

ID

ZDB-FIG-100504-28

Publication

Carney et al., 2010 - Genetic analysis of fin development in zebrafish identifies furin and hemicentin1 as potential novel Fraser Syndrome disease genes

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Fig. 6

Conserved and redundant roles of zebrafish Grip1/2 proteins.

Lateral views of embryos stained by in situ hybridisation with probes against grip1 (A) and grip2 (B,C) at 2-cell stage (B) and 24 hpf (A,C). grip1 is expressed in the fin fold (A) whilst grip2 is broadly expressed at 24 hpf (C). grip2 is maternally deposited in a vegetal domain (B). (D–G) Lateral views of an uninjected WT embryo (D) or embryos injected with morpholinos against grip1 (E), grip2 (F) or both grip1 and grip2 (G) at 32 hpf, demonstrating that whilst grip2 can fully compensate for loss of grip1 function in fin fold integrity (E), loss of grip2 alone (F), or combined loss of both proteins (G) generates moderate to severe fin fold blistering respectively.

Expression Data

Genes:	grip1 grip2a
Fish:	WT
Anatomical Terms:	median fin fold somite whole organism
Stage Range:	2-cell to Prim-5

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	WT + MO1-grip1 WT + MO1-grip2a WT + MO1-grip1 + MO1-grip2a
Knockdown Reagents:	MO1-grip1 MO1-grip2a
Observed In:	medial fin morphogenesis median fin fold
Stage:	Prim-15

Phenotype Detail

Acknowledgments

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