Gene
grip2a
- ID
- ZDB-GENE-081104-132
- Name
- glutamate receptor interacting protein 2a
- Symbol
- grip2a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Acts upstream of or within cytoskeleton organization; fin morphogenesis; and germ cell migration. Predicted to be located in cytoplasm. Is expressed in oocyte stage I; oocyte stage II; oocyte stage III; unfertilized egg; and yolk. Orthologous to human GRIP2 (glutamate receptor interacting protein 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| ihb465 | Allele with one deletion | Exon 8 | Unknown | CRISPR | |
| ihb476 | Allele with one deletion | Exon 9 | Unknown | CRISPR | |
| la026685Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la029520Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| p06ucal | Allele with one point mutation | Exon 4 | Premature Stop | ENU | |
| p08ajug | Allele with one point mutation | Exon 12 | Premature Stop | ENU | |
| sa883 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa15003 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21192 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa21193 | Allele with one point mutation | Unknown | Splice Site | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-grip2a | Zebrafish Nomenclature Committee | |
| CRISPR2-grip2a | Zebrafish Nomenclature Committee | |
| MO1-grip2a | N/A | Carney et al., 2010 |
| MO2-grip2a | N/A | Carney et al., 2010 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glutamate receptor-interacting protein 1/2 | PDZ domain | PDZ domain 6 | PDZ superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z0I1 | InterPro | 1058 | ||||
| UniProtKB:A0A8M6Z252 | InterPro | 903 | ||||
| UniProtKB:A0A8M6Z7M8 | InterPro | 1100 | ||||
| UniProtKB:B0V3R3 | InterPro | 736 | ||||
| UniProtKB:A0AB13ABL6 | InterPro | 1100 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
grip2a-201
(1)
|
Ensembl | 3,124 nt | ||
| mRNA |
grip2a-202
(1)
|
Ensembl | 3,703 nt | ||
| mRNA |
grip2a-205
(1)
|
Ensembl | 564 nt | ||
| ncRNA |
grip2a-001
(1)
|
Ensembl | 603 nt | ||
| ncRNA |
grip2a-005
(1)
|
Ensembl | 736 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-250D21 | ZFIN Curated Data | |
| Contained in | BAC | CH211-150E8 | ZFIN Curated Data | |
| Encodes | EST | fi03h07 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001430888 (1) | 4327 nt | ||
| Genomic | GenBank:BX469901 (1) | 180553 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z7M8 (1) | 1100 aa |
- Nair, S., Welch, E.L., Moravec, C.E., Trevena, R.L., Hansen, C.L., Pelegri, F. (2023) The midbody component Prc1-like is required for microtubule reorganization during cytokinesis and dorsal determinant segregation in the early zebrafish embryo. Development (Cambridge, England). 150(4)
- Saraswathy, V.M., Zhou, L., McAdow, A.R., Burris, B., Dogra, D., Reischauer, S., Mokalled, M.H. (2022) Myostatin is a negative regulator of adult neurogenesis after spinal cord injury in zebrafish. Cell Reports. 41:111705111705
- Holler, K., Neuschulz, A., Drewe-Boß, P., Mintcheva, J., Spanjaard, B., Arsiè, R., Ohler, U., Landthaler, M., Junker, J.P. (2021) Spatio-temporal mRNA tracking in the early zebrafish embryo. Nature communications. 12:3358
- Lee, H.J., Hou, Y., Chen, Y., Dailey, Z.Z., Riddihough, A., Jang, H.S., Wang, T., Johnson, S.L. (2020) Regenerating zebrafish fin epigenome is characterized by stable lineage-specific DNA methylation and dynamic chromatin accessibility. Genome biology. 21:52
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Shao, M., Wang, M., Liu, Y.Y., Ge, Y.W., Zhang, Y.J., Shi, D.L. (2017) Vegetally localised Vrtn functions as a novel repressor to modulate bmp2b transcription during dorsoventral patterning in zebrafish.. Development (Cambridge, England). 144:3361-3374
- Campbell, P.D., Heim, A.E., Smith, M.Z., Marlow, F.L. (2015) Kinesin-1 interacts with Bucky ball to form germ cells and is required to pattern the zebrafish body axis. Development (Cambridge, England). 142(17):2996-3008
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ge, X., Grotjahn, D., Welch, E., Lyman-Gingerich, J., Holguin, C., Dimitrova, E., Abrams, E.W., Gupta, T., Marlow, F.L., Yabe, T., Adler, A., Mullins, M.C., Pelegri, F. (2014) Hecate/Grip2a acts to reorganize the cytoskeleton in the symmetry-breaking event of embryonic axis induction. PLoS Genetics. 10(6):e1004422
- Welch, E., Pelegri, F. (2014) Cortical depth and differential transport of vegetally localized dorsal and germ line determinants in the zebrafish embryo. Bioarchitecture. 5(1-2):13-26
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