FIGURE

Fig. 4

ID

ZDB-FIG-100430-1

Publication

Quintana et al., 2010 - Adaptive autoimmunity and foxp3-based immunoregulation in zebrafish

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Fig. 4

AHR controls zFoxp3 expression.

(A,B) TCDD was added to the water of three-day post-fertilization zebrafish embryos, and 72 h later zFoxp3 (A) and IL-17 (B) expression were determined by real time PCR (mean + s.d. of triplicates normalized to GAPDH expression). Two independent experiments produced similar results. (C) Fourteen days after immunization, kidney cells from PBS or zCNS immunized zebrafish, or TCDD-treated zCNS immunized zebrafish were analyzed by FACS and cells in the lymphocyte fraction (blue gate) were sorted. (D–E) Expression of zFoxp3 and IL-17 measured by real-time PCR in FACS-sorted lymphocytes. Two independent experiments produced similar results.

Expression Data

Gene:	foxp3a
Fish:	WT
Condition:	chemical treatment: 2,3,7,8-tetrachlorodibenzodioxine
Anatomical Term:	whole organism
Stage:	Protruding-mouth

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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