Fig. S1

Endogenous expression of the hoxc4a gene in zebrafish embryos and larvae. The otic placode is marked by an asterisk. The level of sections are indicated by the red lines. A. Expression analysis of hoxc4a at 1 dpf reveals specific distribution of transcripts in the hindbrain r7, r8 and in the spinal cord. Sections revealed further transcripts in the epibranchial placodes (black arrow), in the paraxial mesoderm underlying the epibranchial placodes and in lateral line neuromasts (blue arrow). B. At 2 dpf strong hoxc4a expression is visible in the hindbrain and in the pharyngeal arches 6 and 7. B′. A section on second somite level shows expression in the developing pectoral fins. C. Hoxc4a expression at 3 dpf. C′. Transcripts are strongly distributed throughout the hindbrain and in addition in the vagal ganglion (black arrow). C″. A section on third somite level shows strong expression in the hindbrain and in the pectoral fins (blue arrow).