FIGURE

Fig. 7

ID

ZDB-FIG-100422-61

Publication

Schonthaler et al., 2010 - The zebrafish mutant bumper shows a hyperproliferation of lens epithelial cells and fibre cell degeneration leading to functional blindness

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Fig. 7

bum^-/- zebrafish are severely visually impaired. (A–B) Lateral (A) and dorsal (B) views of adult bum^-/- mutant zebrafish and sibling (wild-type) zebrafish swimming together. Note the significantly darker overall appearance of the mutant fish (asterisks; lower individual in A and upper individual in B, respectively) compared to their siblings when kept under bright light conditions. (C–F) Optokinetic response of bum^-/- mutants and siblings at 5 dpf (C, D) and 7 dpf (E, F). Both contrast sensitivity (C, E) and visual acuity (D, F) are affected by the mutation. In both paradigms the eye velocity as a measure of visual performance is lower in bum^-/- mutant larvae compared to their siblings. The inset in C shows a schematic representation of the experimental set-up.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	bum^tg413/tg413
Observed In:	detection of light stimulus optokinetic behavior
Stage Range:	Day 5 to Adult

Phenotype Detail

Acknowledgments

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Reprinted from Mechanisms of Development, 127(3-4), Schonthaler, H.B., Franz-Odendaal, T.A., Hodel, C., Gehring, I., Geisler, R., Schwarz, H., Neuhauss, S.C., and Dahm, R., The zebrafish mutant bumper shows a hyperproliferation of lens epithelial cells and fibre cell degeneration leading to functional blindness, 203-219, Copyright (2010) with permission from Elsevier. Full text @ Mech. Dev.