FIGURE

Fig. 8

ID

ZDB-FIG-100422-34

Publication

Harvey et al., 2010 - no tail integrates two modes of mesoderm induction

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Fig. 8

A model of ntl regulation. (A) The ntl promoter contains two different regulatory elements that activate ntl expression in the developing margin. BMP and Wnt signalling acts through one element (E1, shown in green) to activate ntl expression in the ventral margin. Nodal signalling induces ntl expression via a separate regulatory element (E2, shown in red), resulting in an enrichment of expression in the dorsal margin. (B) BMP and Wnt induction of ntl is required for tail mesoderm formation (shown in green). Anterior mesoderm (shown in red) results from the induction of ntl and ntl expression by nodal signalling. Notochord formation (shown in yellow) is dependent on regulatory elements that also lie within E2 of the ntl promoter.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Phenotype Detail

Acknowledgments

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