FIGURE

Fig. 8

ID

ZDB-FIG-100302-83

Publication

Bai et al., 2010 - Disruption of zebrafish cyclin G-associated kinase (GAK) function impairs the expression of Notch-dependent genes during neurogenesis and causes defects in neuronal development

Other Figures

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Fig. 8

Programmed cell death in wild-type and GAK morphant embryos during development. (A, C) Lateral and (B, D) dorsal views of TUNEL-stained (A, B) wild-type and (C, D) GAK morphant embryos at the 14-somite stage. At this stage, the control embryos display no detectable apoptosis, whereas GAK morphants have a low level of programmed cell death (indicated by black arrowheads). (E, G) Lateral and (F, H) dorsal views of TUNEL-stained (E, F) wild-type and (G, H) GAK morphants at 24 hpf. While the control animal exhibits a low level of apoptosis in anterior brain and the posterior body regions (arrowheads), GAK morphants exhibit a high level of apoptotic cell death in the brain, as well as in the neural tube (arrowheads). However, as compared to the control wild-type embryo, no obvious increase in apoptosis was observed in the posterior region of GAK morphants (indicated by arrows). In all the lateral views, anterior is to the left and dorsal is up. ey, eye; Hb, hindbrain; MHB, mid-hindbrain boundary; nt, neural tube; s, somites; tb, tailbud. Scale Bar, 100 m.

Expression Data

Expression Detail

Antibody Labeling

Phenotype Data

Fish:	AB + MO1-gak
Knockdown Reagent:	MO1-gak
Observed In:	apoptotic process
Stage Range:	14-19 somites to Prim-5

Phenotype Detail

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ BMC Dev. Biol.